ip3r 1 Search Results


ip3r antibody  (Proteintech)
95
Proteintech ip3r antibody
Ip3r Antibody, supplied by Proteintech, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ip3r+1/ITPR1-specific+Antibody/pm40851314-123-17-30
Average 95 stars, based on 1 article reviews
ip3r antibody - by Bioz Stars, 2026-09
95/100 stars
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rabbit anti ip3r1 nbp2 22458 antibodies  (Novus Biologicals)
93
Novus Biologicals rabbit anti ip3r1 nbp2 22458 antibodies
(a) Schematic representation of ERMC tethering complexes. Generated with BioRender. (b) Huh7.5 cells were infected with DENV 16681s (MOI=1) or ZIKV H/PF/2013 (MOI=10) or left uninfected. Two or three days later, cells were fixed and subjected to proximity ligation assays (PLA) to detect SYNJ2BP-RRBP1 interactions, and immunostained for NS3 viral protein to identify infected cells. Cells were imaged using confocal microscopy. Representative images are shown. Scale bar=20 µm. (c) Quantification of PLA dot abundance for RRBP1-SYNJ2BP, VAPB-PTPIP51 and <t>IP3R1-VDAC1</t> interactions in uninfected-and infected-cells from two independent experiments. Values in the 5%-95% percentile range are shown. (d) Cells were prepared as in (b). Two or three days post-infection, cell extracts were prepared, and the expression levels of the indicated proteins were analyzed by western blotting. The arrow indicates the ZIKV-induced SYNJ2BP protein product.
Rabbit Anti Ip3r1 Nbp2 22458 Antibodies, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ip3r+1/IP3R1+Antibody/bio_rxiv__2023__03__09__531853-198-0-7
Average 93 stars, based on 1 article reviews
rabbit anti ip3r1 nbp2 22458 antibodies - by Bioz Stars, 2026-09
93/100 stars
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ip3 r blocker treatment in vitro  (MedChemExpress)
94
MedChemExpress ip3 r blocker treatment in vitro
(a) Schematic representation of ERMC tethering complexes. Generated with BioRender. (b) Huh7.5 cells were infected with DENV 16681s (MOI=1) or ZIKV H/PF/2013 (MOI=10) or left uninfected. Two or three days later, cells were fixed and subjected to proximity ligation assays (PLA) to detect SYNJ2BP-RRBP1 interactions, and immunostained for NS3 viral protein to identify infected cells. Cells were imaged using confocal microscopy. Representative images are shown. Scale bar=20 µm. (c) Quantification of PLA dot abundance for RRBP1-SYNJ2BP, VAPB-PTPIP51 and <t>IP3R1-VDAC1</t> interactions in uninfected-and infected-cells from two independent experiments. Values in the 5%-95% percentile range are shown. (d) Cells were prepared as in (b). Two or three days post-infection, cell extracts were prepared, and the expression levels of the indicated proteins were analyzed by western blotting. The arrow indicates the ZIKV-induced SYNJ2BP protein product.
Ip3 R Blocker Treatment In Vitro, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ip3r+1/IP3+Receptor+Antibody/pm38169563-75-1-9
Average 94 stars, based on 1 article reviews
ip3 r blocker treatment in vitro - by Bioz Stars, 2026-09
94/100 stars
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antibodies anti insp3r1  (Bethyl)
93
Bethyl antibodies anti insp3r1
Figure 3 | Glucagon stimulates CRTC2 activity via PKA-dependent phosphorylation of InsP3Rs. a, b, Immunoblots of <t>InsP3R1</t> immunoprecipitates (IP) using phospho-PKA substrate antiserum to show effect of H89 (a) and Ala mutations (b) at one or both (DM) PKA consensus sites (Ser 1589, Ser 1756) on InsP3R1 phosphorylation in hepatocytes exposed to glucagon (Gcg). Effect of wild-type and PKA-mutant InsP3R1 on calcium mobilization in response to Gcg (b) shown (*P , 0.001; n 5 3). c, d, Effect of wild-type or PKA-defective InsP3R1 (DM) on calcineurin (Calna) activation
Antibodies Anti Insp3r1, supplied by Bethyl, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ip3r+1/IP3R1+Antibody/pm22495310-279-1-10
Average 93 stars, based on 1 article reviews
antibodies anti insp3r1 - by Bioz Stars, 2026-09
93/100 stars
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anti ip3r1  (Novus Biologicals)
92
Novus Biologicals anti ip3r1
Figure 3 | Glucagon stimulates CRTC2 activity via PKA-dependent phosphorylation of InsP3Rs. a, b, Immunoblots of <t>InsP3R1</t> immunoprecipitates (IP) using phospho-PKA substrate antiserum to show effect of H89 (a) and Ala mutations (b) at one or both (DM) PKA consensus sites (Ser 1589, Ser 1756) on InsP3R1 phosphorylation in hepatocytes exposed to glucagon (Gcg). Effect of wild-type and PKA-mutant InsP3R1 on calcium mobilization in response to Gcg (b) shown (*P , 0.001; n 5 3). c, d, Effect of wild-type or PKA-defective InsP3R1 (DM) on calcineurin (Calna) activation
Anti Ip3r1, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ip3r+1/IP3R1+Antibody/10__1523_slash_jneurosci__1882___20__2021-216-34-35
Average 92 stars, based on 1 article reviews
anti ip3r1 - by Bioz Stars, 2026-09
92/100 stars
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itpr1  (Alomone Labs)
93
Alomone Labs itpr1
A. KCC2 protein complexes were isolated from forebrain plasma membrane fractions of 8-12-week-old mice, resolved by BN-PAGE and immunoblotted for selected high risk ASD/Epi risk gene products; ANK2, ANK3, CNTN1, <t>ITPR1,</t> NCKAP1, SCN2A, SHANK3, SPTAN1 and SPTBN1.
Itpr1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ip3r+1/Anti-IP3+Receptor-1+(ITPR1)+Antibody/bio_rxiv__2020__03__02__973859-179-39-42
Average 93 stars, based on 1 article reviews
itpr1 - by Bioz Stars, 2026-09
93/100 stars
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rabbit anti ip3r1  (Novus Biologicals)
94
Novus Biologicals rabbit anti ip3r1
A. KCC2 protein complexes were isolated from forebrain plasma membrane fractions of 8-12-week-old mice, resolved by BN-PAGE and immunoblotted for selected high risk ASD/Epi risk gene products; ANK2, ANK3, CNTN1, <t>ITPR1,</t> NCKAP1, SCN2A, SHANK3, SPTAN1 and SPTBN1.
Rabbit Anti Ip3r1, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ip3r+1/IP3R1+Antibody/pmc04956114-252-14-16
Average 94 stars, based on 1 article reviews
rabbit anti ip3r1 - by Bioz Stars, 2026-09
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anti ip3r  (Novus Biologicals)
94
Novus Biologicals anti ip3r
A. KCC2 protein complexes were isolated from forebrain plasma membrane fractions of 8-12-week-old mice, resolved by BN-PAGE and immunoblotted for selected high risk ASD/Epi risk gene products; ANK2, ANK3, CNTN1, <t>ITPR1,</t> NCKAP1, SCN2A, SHANK3, SPTAN1 and SPTBN1.
Anti Ip3r, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ip3r+1/IP3R1+Antibody/pmc12847789-426-0-6
Average 94 stars, based on 1 article reviews
anti ip3r - by Bioz Stars, 2026-09
94/100 stars
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nbp2-22458  (novus biologicals)
92
novus biologicals nbp2-22458

Nbp2 22458, supplied by novus biologicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ip3r+1/IP3R1+Antibody/pmc11743106-9-0-3
Average 92 stars, based on 1 article reviews
nbp2-22458 - by Bioz Stars, 2026-09
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anti rabbit pplcg1  (Boster Bio)
91
Boster Bio anti rabbit pplcg1

Anti Rabbit Pplcg1, supplied by Boster Bio, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ip3r+1/Anti-Phospho-IP3R-I+(S1598)+ITPR1+Antibody/pm37028406-310-4-11
Average 91 stars, based on 1 article reviews
anti rabbit pplcg1 - by Bioz Stars, 2026-09
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pflag-cmv2 ip 3 r1 gk (bovine)  (POSTECH Inc)
90
POSTECH Inc pflag-cmv2 ip 3 r1 gk (bovine)

Pflag Cmv2 Ip 3 R1 Gk (Bovine), supplied by POSTECH Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ip3r+1/pflag+cmv2+ip3r1+sd++bovine+/pmc12069674-34-0-11
Average 90 stars, based on 1 article reviews
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rabbit polyclonal antibody specific to ip3r1  (KU Leuven)
90
KU Leuven rabbit polyclonal antibody specific to ip3r1

Rabbit Polyclonal Antibody Specific To Ip3r1, supplied by KU Leuven, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ip3r+1/primary+antibody+against+ip3r1/10__7554_slash_elife__88082-281-24-33
Average 90 stars, based on 1 article reviews
rabbit polyclonal antibody specific to ip3r1 - by Bioz Stars, 2026-09
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Image Search Results


(a) Schematic representation of ERMC tethering complexes. Generated with BioRender. (b) Huh7.5 cells were infected with DENV 16681s (MOI=1) or ZIKV H/PF/2013 (MOI=10) or left uninfected. Two or three days later, cells were fixed and subjected to proximity ligation assays (PLA) to detect SYNJ2BP-RRBP1 interactions, and immunostained for NS3 viral protein to identify infected cells. Cells were imaged using confocal microscopy. Representative images are shown. Scale bar=20 µm. (c) Quantification of PLA dot abundance for RRBP1-SYNJ2BP, VAPB-PTPIP51 and IP3R1-VDAC1 interactions in uninfected-and infected-cells from two independent experiments. Values in the 5%-95% percentile range are shown. (d) Cells were prepared as in (b). Two or three days post-infection, cell extracts were prepared, and the expression levels of the indicated proteins were analyzed by western blotting. The arrow indicates the ZIKV-induced SYNJ2BP protein product.

Journal: bioRxiv

Article Title: Flaviviruses alter endoplasmic reticulum-mitochondria contacts to regulate respiration and apoptosis

doi: 10.1101/2023.03.09.531853

Figure Lengend Snippet: (a) Schematic representation of ERMC tethering complexes. Generated with BioRender. (b) Huh7.5 cells were infected with DENV 16681s (MOI=1) or ZIKV H/PF/2013 (MOI=10) or left uninfected. Two or three days later, cells were fixed and subjected to proximity ligation assays (PLA) to detect SYNJ2BP-RRBP1 interactions, and immunostained for NS3 viral protein to identify infected cells. Cells were imaged using confocal microscopy. Representative images are shown. Scale bar=20 µm. (c) Quantification of PLA dot abundance for RRBP1-SYNJ2BP, VAPB-PTPIP51 and IP3R1-VDAC1 interactions in uninfected-and infected-cells from two independent experiments. Values in the 5%-95% percentile range are shown. (d) Cells were prepared as in (b). Two or three days post-infection, cell extracts were prepared, and the expression levels of the indicated proteins were analyzed by western blotting. The arrow indicates the ZIKV-induced SYNJ2BP protein product.

Article Snippet: Rabbit anti-IP3R1 (NBP2-22458) antibodies were obtained from Novus Biologicals.

Techniques: Generated, Infection, Ligation, Confocal Microscopy, Expressing, Western Blot

(a) Fixed Huh7.5 cells stably expressingmito-mTurquoise2 (exhibiting fluorescent mitochondria) were subjected to PLAs detecting VDAC1-IP3R1, SYNJ2BP-RRBP1 and VAPB-PTPIP51 interactions. Scale bar = 10 µm. (b,c) Huh7.5 cells were infected with DENV 16681s (MOI=1) or ZIKV H/PF/2013 (MOI=10), or left uninfected. Two days later, cells were fixed and subjected to proximity ligation assays (PLA) to detect (b) VDAC1/IP3R1 or (c) PTPIP51/VAB interactions, and immunostained for NS3 viral protein to identify infected cells. Cells were imaged using confocal microscopy. Representative images are shown.

Journal: bioRxiv

Article Title: Flaviviruses alter endoplasmic reticulum-mitochondria contacts to regulate respiration and apoptosis

doi: 10.1101/2023.03.09.531853

Figure Lengend Snippet: (a) Fixed Huh7.5 cells stably expressingmito-mTurquoise2 (exhibiting fluorescent mitochondria) were subjected to PLAs detecting VDAC1-IP3R1, SYNJ2BP-RRBP1 and VAPB-PTPIP51 interactions. Scale bar = 10 µm. (b,c) Huh7.5 cells were infected with DENV 16681s (MOI=1) or ZIKV H/PF/2013 (MOI=10), or left uninfected. Two days later, cells were fixed and subjected to proximity ligation assays (PLA) to detect (b) VDAC1/IP3R1 or (c) PTPIP51/VAB interactions, and immunostained for NS3 viral protein to identify infected cells. Cells were imaged using confocal microscopy. Representative images are shown.

Article Snippet: Rabbit anti-IP3R1 (NBP2-22458) antibodies were obtained from Novus Biologicals.

Techniques: Stable Transfection, Infection, Ligation, Confocal Microscopy

Figure 3 | Glucagon stimulates CRTC2 activity via PKA-dependent phosphorylation of InsP3Rs. a, b, Immunoblots of InsP3R1 immunoprecipitates (IP) using phospho-PKA substrate antiserum to show effect of H89 (a) and Ala mutations (b) at one or both (DM) PKA consensus sites (Ser 1589, Ser 1756) on InsP3R1 phosphorylation in hepatocytes exposed to glucagon (Gcg). Effect of wild-type and PKA-mutant InsP3R1 on calcium mobilization in response to Gcg (b) shown (*P , 0.001; n 5 3). c, d, Effect of wild-type or PKA-defective InsP3R1 (DM) on calcineurin (Calna) activation

Journal: Nature

Article Title: Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

doi: 10.1038/nature10988

Figure Lengend Snippet: Figure 3 | Glucagon stimulates CRTC2 activity via PKA-dependent phosphorylation of InsP3Rs. a, b, Immunoblots of InsP3R1 immunoprecipitates (IP) using phospho-PKA substrate antiserum to show effect of H89 (a) and Ala mutations (b) at one or both (DM) PKA consensus sites (Ser 1589, Ser 1756) on InsP3R1 phosphorylation in hepatocytes exposed to glucagon (Gcg). Effect of wild-type and PKA-mutant InsP3R1 on calcium mobilization in response to Gcg (b) shown (*P , 0.001; n 5 3). c, d, Effect of wild-type or PKA-defective InsP3R1 (DM) on calcineurin (Calna) activation

Article Snippet: The antibodies anti-InsP3R1 (A302–158A) and InsP3R3 (A302–160A) were purchased from Bethyl Laboratories, anti-InsP3R2 (ab77838) from Abcam, anti-calcineurin (610260) from BD Biosciences, antiGRP78 (ADI-SPA-826-F) from Enzo Life Sciences, anti-phospho-PKA substrate (RRXS/T, 9624), anti-phospho-AKT substrate (RXXS/T, 9614) and CRTC2 (pS171, 2892) from Cell Signaling.

Techniques: Activity Assay, Phospho-proteomics, Western Blot, Mutagenesis, Activation Assay

A. KCC2 protein complexes were isolated from forebrain plasma membrane fractions of 8-12-week-old mice, resolved by BN-PAGE and immunoblotted for selected high risk ASD/Epi risk gene products; ANK2, ANK3, CNTN1, ITPR1, NCKAP1, SCN2A, SHANK3, SPTAN1 and SPTBN1.

Journal: bioRxiv

Article Title: The K-Cl co-transporter 2 is a point of convergence for multiple autism spectrum disorder and epilepsy risk gene products

doi: 10.1101/2020.03.02.973859

Figure Lengend Snippet: A. KCC2 protein complexes were isolated from forebrain plasma membrane fractions of 8-12-week-old mice, resolved by BN-PAGE and immunoblotted for selected high risk ASD/Epi risk gene products; ANK2, ANK3, CNTN1, ITPR1, NCKAP1, SCN2A, SHANK3, SPTAN1 and SPTBN1.

Article Snippet: The following antibodies were used for immunoprecipitation (IP), immunoblot (IB), or immunocytochemistry (ICC): ANK2 (mouse, ICC, Invitrogen 33-3700), ANK2 (rabbit, IB, Bioss BS-6967R-TR), ANK3 (mouse, ICC, Neuromab 75-146), ANK3 (rabbit, IB, Synaptic Systems 386003), CNTN1 (rabbit, IB/ICC, Abcam Ab66265), ITPR1 (rabbit, IB/ICC, Alomone ACC-019), KCC2 (mouse, IP/ICC, Neuromab 75-013), KCC2 (rabbit, IB/ICC, Millipore 07-432), NCKAP1 (rabbit, IB, Abcam 126061), NCKAP1 (rabbit, ICC, Sigma HPA020449), SCN2A (mouse, ICC, Neuromab 75-024), SCN2A (rabbit, IB, Alomone ASC-002), SHANK3 (rabbit, IB/ICC, Alomone APZ-013), SPTAN1 (mouse, ICC, Abcam Ab11755), SPTAN1 (rabbit, IB, Cell Signaling 21225), SPTBN1 (rabbit, IB/ICC, Abcam Ab72239), α-Tubulin (mouse, IB, Sigma T9026).

Techniques: Isolation, Clinical Proteomics, Membrane

A. Primary cultured neurons from P1 pups were infected with CAMKII AAV-GFP at DIV 3 (to visualize cell morphology and to identify excitatory neurons) and fixed at DIV 21. The cells were immunostained for KCC2 and high risk ASD/Epi risk gene products; ANK2, ANK3, CNTN1, ITPR1, NCKAP1, SCN2A, SHANK3, SPTAN1 and SPTBN1 (n=3).

Journal: bioRxiv

Article Title: The K-Cl co-transporter 2 is a point of convergence for multiple autism spectrum disorder and epilepsy risk gene products

doi: 10.1101/2020.03.02.973859

Figure Lengend Snippet: A. Primary cultured neurons from P1 pups were infected with CAMKII AAV-GFP at DIV 3 (to visualize cell morphology and to identify excitatory neurons) and fixed at DIV 21. The cells were immunostained for KCC2 and high risk ASD/Epi risk gene products; ANK2, ANK3, CNTN1, ITPR1, NCKAP1, SCN2A, SHANK3, SPTAN1 and SPTBN1 (n=3).

Article Snippet: The following antibodies were used for immunoprecipitation (IP), immunoblot (IB), or immunocytochemistry (ICC): ANK2 (mouse, ICC, Invitrogen 33-3700), ANK2 (rabbit, IB, Bioss BS-6967R-TR), ANK3 (mouse, ICC, Neuromab 75-146), ANK3 (rabbit, IB, Synaptic Systems 386003), CNTN1 (rabbit, IB/ICC, Abcam Ab66265), ITPR1 (rabbit, IB/ICC, Alomone ACC-019), KCC2 (mouse, IP/ICC, Neuromab 75-013), KCC2 (rabbit, IB/ICC, Millipore 07-432), NCKAP1 (rabbit, IB, Abcam 126061), NCKAP1 (rabbit, ICC, Sigma HPA020449), SCN2A (mouse, ICC, Neuromab 75-024), SCN2A (rabbit, IB, Alomone ASC-002), SHANK3 (rabbit, IB/ICC, Alomone APZ-013), SPTAN1 (mouse, ICC, Abcam Ab11755), SPTAN1 (rabbit, IB, Cell Signaling 21225), SPTBN1 (rabbit, IB/ICC, Abcam Ab72239), α-Tubulin (mouse, IB, Sigma T9026).

Techniques: Cell Culture, Infection

A. Total forebrain lysates and plasma membrane lysates were resolved by SDS-PAGE and immunoblotted for selected high risk ASD/Epi risk gene product; ANK2, ANK3, CNTN1, ITPR1, NCKAP1, SCN2A, SHANK3, SPTAN1 and SPTBN1. B. The expression levels for each protein were quantified using densitometry and normalized to α-Tubulin loading controls (n=3). KCC2 (p=0.037), ANK3-190 (p=0.0014), CNTN1 (p=0.011), and ITPR1 (p=0.016) were significantly reduced in plasma membrane fractions.

Journal: bioRxiv

Article Title: The K-Cl co-transporter 2 is a point of convergence for multiple autism spectrum disorder and epilepsy risk gene products

doi: 10.1101/2020.03.02.973859

Figure Lengend Snippet: A. Total forebrain lysates and plasma membrane lysates were resolved by SDS-PAGE and immunoblotted for selected high risk ASD/Epi risk gene product; ANK2, ANK3, CNTN1, ITPR1, NCKAP1, SCN2A, SHANK3, SPTAN1 and SPTBN1. B. The expression levels for each protein were quantified using densitometry and normalized to α-Tubulin loading controls (n=3). KCC2 (p=0.037), ANK3-190 (p=0.0014), CNTN1 (p=0.011), and ITPR1 (p=0.016) were significantly reduced in plasma membrane fractions.

Article Snippet: The following antibodies were used for immunoprecipitation (IP), immunoblot (IB), or immunocytochemistry (ICC): ANK2 (mouse, ICC, Invitrogen 33-3700), ANK2 (rabbit, IB, Bioss BS-6967R-TR), ANK3 (mouse, ICC, Neuromab 75-146), ANK3 (rabbit, IB, Synaptic Systems 386003), CNTN1 (rabbit, IB/ICC, Abcam Ab66265), ITPR1 (rabbit, IB/ICC, Alomone ACC-019), KCC2 (mouse, IP/ICC, Neuromab 75-013), KCC2 (rabbit, IB/ICC, Millipore 07-432), NCKAP1 (rabbit, IB, Abcam 126061), NCKAP1 (rabbit, ICC, Sigma HPA020449), SCN2A (mouse, ICC, Neuromab 75-024), SCN2A (rabbit, IB, Alomone ASC-002), SHANK3 (rabbit, IB/ICC, Alomone APZ-013), SPTAN1 (mouse, ICC, Abcam Ab11755), SPTAN1 (rabbit, IB, Cell Signaling 21225), SPTBN1 (rabbit, IB/ICC, Abcam Ab72239), α-Tubulin (mouse, IB, Sigma T9026).

Techniques: Clinical Proteomics, Membrane, SDS Page, Expressing

Journal: iScience

Article Title: Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis

doi: 10.1016/j.isci.2024.111599

Figure Lengend Snippet:

Article Snippet: Rabbit anti-IP3R1 , Novus Biologicals , NBP2-22458.

Techniques: Produced, Virus, Recombinant, Software